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KMID : 0358420080510070771
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 7 p.771 ~ p.776
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Fetal ductus arteriosus constriction and heart failure following maternal cyclooxygenase-2 inhibitor ingestion
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Lee Min-A
Kil Hong-Ryang
Rhee Yun-Ee
Jang Mi-Young
Ko Young-Bok
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Abstract
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We report a case of premature constriction of the fetal ductus arteriosus following maternal ingestion of a cyclooxygenase-2 (COX-2) inhibitor at 37 weeks’ gestation. Fetal sonography at 38+2 weeks’ gestation revealed tricuspid regurgitation, absent transpulmonary valve flow, right heart enlargement, and pericardial effusion. An immediate delivery resulted in a good postnatal outcome with dramatic improvement in the clinical and echocardiographic findings. Maternal exposure to Non-steroidal anti-inflammatory drugs (NSAIDs), especially late in gestation, can cause premature constriction of the ductus arteriosus, heart failure, and fetal death. Therefore, the use of NSAIDs late in gestation should be considered in limited cases with close fetal heart monitoring.
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KEYWORD
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Ductus arteriosus, Non-steroidal anti-inflammatory drugs, Cyclooxygenase-2 inhibitor, Nimesulide
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